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MI-3454

CAT: 0013-GTR19189387Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19189387Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MI-3454 is a potent, selective, and orally bioavailable Menin-MLL1 interaction inhibitor. It demonstrates anti-proliferative and differentiation-inducing activity in vitro against acute leukemia cells harboring MLL1 rearrangements or NPM1 mutations. In vivo studies in murine leukemia models show it can induce remission by downregulating key leukemogenic genes.
CAS Number
2134169-43-8
Product Name Alternative
MI 3454, MI3454, MI-3454, HistoneMethyltransferase, Histone Methyltransferase, Menin-MLL
Field of Research
Epigenetics & Chromatin
Purity
99.68% (May vary between batches)
Solubility
DMSO:20 mg/mL (31.41 mM)
Smiles
CNc1nc (NC2CCN (Cc3ccc4n (CC56CC (C5) (C6) NC=O) c (cc4c3C) C#N) CC2) c2cc (CC (F) (F) F) sc2n1
Molecular Formula
C32H35F3N8OS
Molecular Weight
636.73
Storage Conditions
-20°C
Notes
For research use only.

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