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CAY10498

CAT: 0931-T37669-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0931-T37669-01Size:500 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
863202-33-9
Target
Others|||Adenosine Receptor
Related Pathways
Others|||GPCR/G Protein|||Neuroscience
Bioactivity
The A1, A2A, A2B, and A3 adenosine receptors (ARs) are ubiquitous G protein-coupled receptors. The four AR subtypes have been implicated in several areas of therapeutic interest such as stroke and other ischemic conditions, as well as inflammation, neurodegenerative diseases, diabetes, and sleep regulation. A3 AR antagonists are of interest as therapeutic agents in glaucoma agents and inflammation. CAY10498 is a potent and selective A3 AR antagonist exhibiting a Ki of 37 nM with 60 and 200-fold selectivity over A1 and A2A adenosine receptors, respectively. CAY10498 is also a structural analog of reversine, a dedifferentiation agent of embryonic progenitor cells. However, no dedifferentiation effects or any connection between A3 AR antagonism and dedifferentiation have been demonstrated.
Smiles
N(C1=C2C(=NC(NC3=CC=CC=C3)=N1)N=CN2)[C@H]4[C@@]5(C[C@](C4)(CC5)[H])[H]
Molecular Formula
C18H20N6
Molecular Weight
320.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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