5?-Dihydroprogesterone

CAT: 0931-MF-0042974-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0042974-01Size:100 mg
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CAS Number
128-23-4
Target
Others|||Oxytocin Receptor
Related Pathways
Others|||Endocrinology/Hormones|||GPCR/G Protein
Bioactivity
5?-Dihydroprogesterone (5?-DHP) is a progesterone receptor agonist and metabolite of progesterone .1,2It is formed from progesterone by 5?-reductase.25?-DHP inhibits spontaneous contractions in isolated rat uterus when used at a concentration of 10 ?g/ml, an effect that can be blocked by the progesterone receptor antagonist RU486 but not the GABAAreceptor antagonist picrotoxin .1It is a negative modulator of homooligomeric ?1 subunit-containing GABAAreceptors, inhibiting GABA-induced currents inX. laevisoocytes expressing these receptors (IC50= 5.02 ?M) .3Plasma levels of 5?-DHP decrease at the onset of spontaneous human labor.4
Smiles
[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])CC(=O)CC[C@]12C
Molecular Formula
C21H32O2
Molecular Weight
316.485
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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