Products for Research Use Only
RegisterLogin

Sorafenib N-oxide

CAT: 0931-T36681-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T36681-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
583840-03-3
Target
Drug Metabolite, Others, Cytochromes P450
Related Pathways
Others, Metabolism
Bioactivity
Sorafenib N-oxide is an active metabolite of sorafenib , an inhibitor of Raf-1, B-RAF, and receptor tyrosine kinases. Sorafenib N-oxide inhibits FLT3 that contains the internal tandem duplication mutation (FLT3-ITD; Kd = 70 nM) and inhibits proliferation of MV4-11 acute myeloid leukemia (AML) cells expressing FLT3-ITD (IC50 = 25.8 nM) . It is selective for AML cell lines containing FLT3-ITD over lines containing wild-type FLT3 (IC50s = 3.9-13.3 μM) . Sorafenib N-oxide is also a linear-mixed inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 (Ki = 15 μM in human liver microsomes) .
Smiles
CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1=O
Molecular Formula
C21H16ClF3N4O4
Molecular Weight
480.83
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T0093L-01Sorafenib
T0093-01Sorafenib tosylate
T12976-01Sorafenib-d4
TSH-00132-01N, N-Dimethyldecylamine N-oxide
T40512Echimidine N-oxide
T124559-01Fumaritine N-oxide
T123864-01Lycopsamine N-oxide
T11351-01Galanthamine N-Oxide
T126510-01Crebanine N-oxide
T37432Erythromycin A N-oxide

Alternative Products

CatalogName
FS27857-01Sorafenib N-oxide
AR-S01787-01Sorafenib-N-oxide
A12005-1Sorafenib N-Oxide 1mg
CS-O-46110Sorafenib N-Oxide 13CD3
A12005-5Sorafenib N-Oxide 5mg
AR-S09465-01Sorafenib N-Oxide 13C-D3
TRC-D293295-25MGN-Desmethyl Sorafenib (Pyridine)-N-oxide
CS-T-88299N-Desmethyl Sorafenib (Pyridine) -N-oxide
458828N-Desmethyl Sorafenib (Pyridine) -N-oxide-d4
TRC-D293297-25MGN-Desmethyl Sorafenib (Pyridine)-N-oxide-d4

Popular Products