PR-104

• Target:

  Others|||DNA Alkylator/Crosslinker

• Related Pathways:

  Others|||DNA Damage/DNA Repair

• Bioactivity:

  PR-104 is a highly specific hypoxia-activated agent that cross-links DNA, enabling its application in various tumor xenograft models. Functioning as a pre-prodrug of nitrogen mustard, PR-104 undergoes efficient conversion to the dinitrobenzamide mustards alcohol form, known as PR-104A[1].

• Smiles:

  N(CCOS(C)(=O)=O)(CCBr)C1=C(C(NCCOP(=O)(O)O)=O)C=C(N(=O)=O)C=C1N(=O)=O

• Molecular Formula:

  C14H20BrN4O12PS

• Molecular Weight:

  579.27

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  851627-62-8