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PR-104 (sodium)

CAT: 0804-HY-16406Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-16406Size:1 Each
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Description
PR-104 (sodium) is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104 (sodium), as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A[1].
CAS Number
851627-80-0
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pr-104-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCOP(O)(O[Na])=O)C1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1N(CCBr)CCOS(=O)(C)=O
Molecular Formula
C14H19BrN4NaO12PS
Molecular Weight
601.25
References & Citations
[1]Patterson AV, et al. Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104. Clin Cancer Res. 2007;13 (13) :3922-3932.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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T40947PR-104 sodium
030162-01Sodium Hydrogen Sulphate Monohydrate 98-104.0%
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B 077-01N⁶- (19- [Biotinyl]amino- 4, 7, 10, 13, 16- pentaoxanonadecyl) adenosine- 5'- O- diphosphate (6-Biotin-20-ADP / 6-[Biotin]-APrO- (EO) ₄-Pr-ADP), sodium salt
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