Products for Research Use Only
RegisterLogin

CAY10744

CAT: 0931-T36195-02Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T36195-02Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2375613-31-1
Target
Topoisomerase, Others
Related Pathways
Others, DNA Damage/DNA Repair
Bioactivity
CAY10744 is a topoisomerase II-α poison.1 It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 μM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 μM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 μM, respectively) . CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 μM. CAY10744 (12 mg/kg per day) reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer.
Smiles
OC1=C2CC=3C(C2=CC=C1)=NC(=CC3C4=CC=C(O)C=C4)C5=C(Cl)C=CC=C5
Molecular Formula
C24H16ClNO2
Molecular Weight
385.84
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

2-(2-chlorophenyl)-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-6-ol
CAS Number2375613-31-1
PubChem CID155534370
IUPAC Name2-(2-chlorophenyl)-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-6-ol
Molecular FormulaC24H16ClNO2
Molecular Weight385.8
XLogP5.7
Topological Polar Surface Area53.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count28
Formal Charge0
Complexity537
SMILES
C1C2=C(C=CC=C2O)C3=C1C(=CC(=N3)C4=CC=CC=C4Cl)C5=CC=C(C=C5)O
InChI
InChI=1S/C24H16ClNO2/c25-21-6-2-1-4-17(21)22-13-18(14-8-10-15(27)11-9-14)20-12-19-16(24(20)26-22)5-3-7-23(19)28/h1-11,13,27-28H,12H2
InChIKey
FEGFONFVHVRWGK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2-chlorophenyl)-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-6-ol
CAS: 2375613-31-1
CID: 155534370
Formula: C24H16ClNO2
MW: 385.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight385.8
XLogP35.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass385.0869564
Monoisotopic Mass385.0869564
Topological Polar Surface Area53.4 Ų
Heavy Atom Count28
Formal Charge0
Complexity537
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T37465-01CAY10742
T37463-01CAY10704
T23860-01CAY10444
T36035-01CAY10784
T36034-01CAY10774
T36197-01CAY10747
T36461-01CAY10748
T36196-01CAY10746
T38371-01CAY10734
T36193-01CAY10717

Alternative Products

CatalogName
GTR19192102-01CAY10744

Popular Products