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CAY10774

CAT: 0931-T36034-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T36034-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Bioactivity
CAY10774 is an inhibitor of the protein-protein interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 (IC50= 15 nM in a homologous time-resolved fret (HTRF) assay) .1It increases the activation of Jurkat cells expressing PD-1 in co-culture with artificial antigen-presenting cells (aAPCs) expressing PD-L1 (EC50= 6.6 μM in a reporter assay) . CAY10774 increases surface expression of PD-1 on primary human CD4+and CD8+T cells co-cultured with aAPCs.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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