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CAY10722

CAT: 0931-T35822-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T35822-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
388086-13-3
Target
Others|||Sirtuin
Related Pathways
Others|||Chromatin/Epigenetic|||DNA Damage/DNA Repair
Bioactivity
CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 ?M) . SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.
Smiles
ClC1=CC(Cl)=C(C=C1)C1=NC2=C(O1)C=CC(NC(=O)CC1=CC=CC=C1)=C2
Molecular Formula
C21H14Cl2N2O2
Molecular Weight
397.25
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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