(2R,4R)-APDC (hydrate)

(2R,4R)-APDC (hydrate)

• UNSPSC Description: (2R,4R)-APDC hydrate ((2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid hydrate) is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC hydrate affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC hydrate can be used in the study of epilepsy and other neurological diseases[1].
• Target Antigen: mGluR
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/2r-4r-apdc-hydrate.html
• Purity: 98.0
• Solubility: H2O : 20 mg/mL (ultrasonic;warming)
• Smiles: O=C([C@@H]1NC[C@](C(O)=O)(N)C1)O.O
• Molecular Weight: 192.17
• References & Citations: [1]Feng Y B, et al. Effects of the group II mGlu receptor agonist 2R, 4R-APDC on dentate gyrus cell proliferation in the adult rat brain after diffuse brain injury[J]. Neurological research, 2011, 33(4): 381-388.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported