(2R,4R)-APDC

(2R,4R)-APDC

• CAS Number: 169209-63-6
• UNSPSC Description: (2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases[1][2].
• Target Antigen: mGluR
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/2r-4r-apdc.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@@H]1NC[C@](C(O)=O)(N)C1)O
• Molecular Weight: 174.15
• References & Citations: [1]Folbergrová J, et al. Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats. Brain Res. 2009 Jun 1;1273:144-54.|[2]Yao H, et al. 2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. Neuroreport. 2007 Sep 17;18(14):1459-62.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported