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(2R,4R) -APDC

CAT: 0804-HY-102091-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-102091-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(2R,4R) -APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R) -APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R) -APDC can be used in the study of epilepsy and other neurological diseases[1][2].
CAS Number
169209-63-6
Product Name Alternative
(2R,4R) -4-Aminopyrrolidine-2,4-dicarboxylic acid
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2r-4r-apdc.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H]1NC[C@](C(O)=O)(N)C1)O
Molecular Formula
C6H10N2O4
Molecular Weight
174.15
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Folbergrová J, et al. Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats. Brain Res. 2009 Jun 1;1273:144-54.|[2]Yao H, et al. 2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. Neuroreport. 2007 Sep 17;18 (14) :1459-62.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR

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