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Halofuginone hydrobromide

CAT: 0931-T3524-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T3524-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
64924-67-0
Target
TGF-beta/Smad, DNA/RNA Synthesis, Sodium Channel, Calcium Channel, Parasite
Related Pathways
DNA Damage/DNA Repair, Membrane transporter/Ion channel, Microbiology/Virology, Stem Cells, Metabolism, Cell Cycle/Checkpoint
Purity
0.9973
Bioactivity
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
Smiles
Br.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O
Molecular Formula
C16H17BrClN3O3.HBr
Molecular Weight
495.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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