Halofuginone hydrobromide

• CAS Number :

  64924-67-0

• Target :

  TGF-beta/Smad|||DNA/RNA Synthesis|||Sodium Channel|||Calcium Channel|||Parasite

• Related Pathways :

  DNA Damage/DNA Repair|||Membrane transporter/Ion channel|||Microbiology/Virology|||Stem Cells|||Metabolism|||Cell Cycle/Checkpoint

• Purity :

  0.9973

• Bioactivity :

  Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.

• Smiles :

  Br.O[C@H]1CCCN[C@@H]1CC(=O)Cn1cnc2cc(Br)c(Cl)cc2c1=O

• Molecular Formula :

  C16H17BrClN3O3.HBr

• Molecular Weight :

  495.59

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C