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HALOFUGINONE LACTATE

CAT: 0931-T8785-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T8785-01Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
82186-71-8
Target
TGF-beta/Smad, Sodium Channel, DNA/RNA Synthesis, Calcium Channel, Parasite
Related Pathways
Membrane transporter/Ion channel, DNA Damage/DNA Repair, Metabolism, Cell Cycle/Checkpoint, Microbiology/Virology, Stem Cells
Purity
0.9996
Bioactivity
HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity
Smiles
CC(O)C(O)=O.O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3
Molecular Formula
C19H23BrClN3O6
Molecular Weight
504.8
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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