HALOFUGINONE LACTATE

• Target:

  TGF-beta/Smad|||Sodium Channel|||DNA/RNA Synthesis|||Calcium Channel|||Parasite

• Related Pathways:

  Membrane transporter/Ion channel|||DNA Damage/DNA Repair|||Metabolism|||Cell Cycle/Checkpoint|||Microbiology/Virology|||Stem Cells

• Purity:

  0.9996

• Bioactivity:

  HALOFUGINONE LACTATE is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.Halofuginone inhibits prolyl-tRNA synthetase in an ATP-dependent manner with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-? activity

• Smiles:

  CC (O) C (O) =O.O=C1N (CC (C[C@@H]2NCCC[C@H]2O) =O) C=NC3=C1C=C (Cl) C (Br) =C3

• Molecular Formula:

  C19H23BrClN3O6

• Molecular Weight:

  504.8

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  82186-71-8