TL12-186

• Target:

  PROTACs|||CDK

• Related Pathways:

  PROTAC|||Cell Cycle/Checkpoint

• Purity:

  0.982

• Bioactivity:

  TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50s of 73 and 55 nM, respectively.

• Smiles:

  O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCC(=O)NCCOCCOCCN4CCN(C5=CC=C(C=C5)NC6=NC=C(Cl)C(=N6)NC=7C=CC=CC7S(=O)(=O)C(C)C)CC4)C3C2=O)CC1

• Molecular Formula:

  C44H51ClN10O9S

• Molecular Weight:

  931.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2250025-88-6