TL12-186

CAT: 0931-MF-0093937-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0093937-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2250025-88-6
Target
PROTACs|||CDK
Related Pathways
PROTAC|||Cell Cycle/Checkpoint
Purity
0.982
Bioactivity
TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50s of 73 and 55 nM, respectively.
Smiles
O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCC(=O)NCCOCCOCCN4CCN(C5=CC=C(C=C5)NC6=NC=C(Cl)C(=N6)NC=7C=CC=CC7S(=O)(=O)C(C)C)CC4)C3C2=O)CC1
Molecular Formula
C44H51ClN10O9S
Molecular Weight
931.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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