OUP-186

• Target:

  Others|||Histamine Receptor

• Related Pathways:

  Immunology/Inflammation|||GPCR/G Protein|||Neuroscience|||Others

• Bioactivity:

  OUP-186 is a high affinity and human/rat species-selective antagonist of histamine H3 receptor. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 ?M. OUP-186 potently induced cell death by activating caspase-3/7. In addition, OUP-186 treatment blocked the proliferation increase triggered by 100 ?M (R) - (-) -?-methylhistamine (H3R agonist) . OUP-186 potently suppresses proliferation and induces caspase-dependent apoptotic death in both ER+ and ER-breast cancer cells.

• Smiles:

  C(CCCNC(SCCCN1CCCCC1)=N)C2=CC=C(Cl)C=C2

• Molecular Formula:

  C19H30ClN3S

• Molecular Weight:

  367.98

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1480830-24-7