OUP-186

CAT: 0931-MF-0042259-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0042259-01Size:25 mg
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CAS Number
1480830-24-7
Target
Others|||Histamine Receptor
Related Pathways
Immunology/Inflammation|||GPCR/G Protein|||Neuroscience|||Others
Bioactivity
OUP-186 is a high affinity and human/rat species-selective antagonist of histamine H3 receptor. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 ?M. OUP-186 potently induced cell death by activating caspase-3/7. In addition, OUP-186 treatment blocked the proliferation increase triggered by 100 ?M (R) - (-) -?-methylhistamine (H3R agonist) . OUP-186 potently suppresses proliferation and induces caspase-dependent apoptotic death in both ER+ and ER-breast cancer cells.
Smiles
C(CCCNC(SCCCN1CCCCC1)=N)C2=CC=C(Cl)C=C2
Molecular Formula
C19H30ClN3S
Molecular Weight
367.98
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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