Products for Research Use Only
RegisterLogin

OUP-186

CAT: 0931-T28275-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T28275-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1480830-24-7
Target
Others, Histamine Receptor
Related Pathways
Immunology/Inflammation, GPCR/G Protein, Neuroscience, Others
Bioactivity
OUP-186 is a high affinity and human/rat species-selective antagonist of histamine H3 receptor. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 μM. OUP-186 potently induced cell death by activating caspase-3/7. In addition, OUP-186 treatment blocked the proliferation increase triggered by 100 μM (R) - (-) -α-methylhistamine (H3R agonist) . OUP-186 potently suppresses proliferation and induces caspase-dependent apoptotic death in both ER+ and ER-breast cancer cells.
Smiles
C(CCCNC(SCCCN1CCCCC1)=N)C2=CC=C(Cl)C=C2
Molecular Formula
C19H30ClN3S
Molecular Weight
367.98
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T33831-01OUP-16
T24087-01GCA-186
T34888-01TL12-186
T26537-01AC-186
T210776-01CRBN ligand-186
T209146-01Antibacterial agent 186
T29605-01Acid Red 186 free acid
T76531-01HBV Seq2 aa:179-186
T207651-01E3 Ligase Ligand-linker Conjugate 186
TMAC-00009-01Anti-Phospho-14-3-3 zeta/delta (Ser184/186) Polyclonal Antibody

Alternative Products

CatalogName
GTR19196840-01OUP-186
MBS5783370OUP-16
564802TL12-186
B2980-5AC-186
5053/10AC 186
BML-FR103-0050MCI-186
ABC-TC0130CERV-186
iha-007Taiwan 186
GTR19200283-01GCA-186

Popular Products