AC-186

CAT: 0026-B2980-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-B2980-5Size:5 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AC-186 is a potent and selective estrogen receptor β (ERβ) agonist. It shows EC₅₀ values of 6 and 5000 nM for ERβ and ERα respectively in functional assays. Decrease in the sex steroids is associated with increased risk of Alzheimer’s disease. AC-186 exhibits gender selective neuroprotection in male animals in a rat model of Parkinson’s disease. AC-186 in combination with ACP-105 increases the amyloid-β degrading enzymes neprilysin and insulin-degrading enzyme, decreases amyloid-β levels in the brain as well as improves cognition in a mouse model of Alzheimer’s Disease.
Shipping Conditions
Gel Pack
Storage Conditions
-20ºC
Shelf Life
36 months

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