Cucurbitacin B

• Target:

  Autophagy|||HIF/HIF Prolyl-Hydroxylase|||COX|||STAT|||PTEN|||Integrin|||Apoptosis|||ROS Kinase|||Endogenous Metabolite|||HIF

• Related Pathways:

  Cytoskeletal Signaling|||Apoptosis|||Immunology/Inflammation|||Tyrosine Kinase/Adaptors|||Stem Cells|||Autophagy|||PI3K/Akt/mTOR signaling|||Chromatin/Epigenetic|||Metabolism|||Angiogenesis|||JAK/STAT signaling|||Neuroscience

• Purity:

  0.9933

• Bioactivity:

  Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.

• Smiles:

  CC (=O) OC (C) (C) C=CC (=O) C (C) (O) C1C (O) CC2 (C) C3CC=C4C (CC (O) C (=O) C4 (C) C) C3 (C) C (=O) CC12C

• Molecular Formula:

  C32H46O8

• Molecular Weight:

  558.7

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  6199-67-3