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Cucurbitacin B

CAT: 0931-T3404-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T3404-01Size:1 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
6199-67-3
Target
Autophagy|||HIF/HIF Prolyl-Hydroxylase|||COX|||STAT|||PTEN|||Integrin|||Apoptosis|||ROS Kinase|||Endogenous Metabolite|||HIF
Related Pathways
Cytoskeletal Signaling|||Apoptosis|||Immunology/Inflammation|||Tyrosine Kinase/Adaptors|||Stem Cells|||Autophagy|||PI3K/Akt/mTOR signaling|||Chromatin/Epigenetic|||Metabolism|||Angiogenesis|||JAK/STAT signaling|||Neuroscience
Purity
0.9933
Bioactivity
Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.
Smiles
CC(=O)OC(C)(C)C=CC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(CC(O)C(=O)C4(C)C)C3(C)C(=O)CC12C
Molecular Formula
C32H46O8
Molecular Weight
558.7
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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