Cucurbitacin B

• Target :

  Autophagy|||HIF/HIF Prolyl-Hydroxylase|||COX|||STAT|||PTEN|||Integrin|||Apoptosis|||ROS Kinase|||Endogenous Metabolite|||HIF

• Related Pathways :

  Cytoskeletal Signaling|||Apoptosis|||Immunology/Inflammation|||Tyrosine Kinase/Adaptors|||Stem Cells|||Autophagy|||PI3K/Akt/mTOR signaling|||Chromatin/Epigenetic|||Metabolism|||Angiogenesis|||JAK/STAT signaling|||Neuroscience

• Purity :

  0.9933

• Bioactivity :

  Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.

• Smiles :

  CC(=O)OC(C)(C)C=CC(=O)C(C)(O)C1C(O)CC2(C)C3CC=C4C(CC(O)C(=O)C4(C)C)C3(C)C(=O)CC12C

• Molecular Formula :

  C32H46O8

• Molecular Weight :

  558.7

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  6199-67-3