Cucurbitacin A

• Target:

  ROCK

• Related Pathways:

  Cytoskeletal Signaling|||Stem Cells|||Cell Cycle/Checkpoint

• Bioactivity:

  Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.

• Smiles:

  [H][C@@]12C[C@H] (O) C (=O) C (C) (C) C1=CC[C@@]1 ([H]) [C@]3 (C) C[C@@H] (O) [C@H] ([C@@] (C) (O) C (=O) \C=C\C (C) (C) OC (C) =O) [C@@]3 (C) CC (=O) [C@@]21CO

• Molecular Formula:

  C32H46O9

• Molecular Weight:

  574.7

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  6040-19-3