Ono 1301

• Target:

  Others|||Prostaglandin Receptor

• Related Pathways:

  GPCR/G Protein|||Immunology/Inflammation|||Others

• Bioactivity:

  Ono 1301 is a prostaglandin I2 mimetic coumpound with inhibitory activity against thromboxane A2 synthase. Ono 1301 suppresses pancreatic fibrosis in the DBTC-induced CP model by inhibiting monocyte activity not only with induction of HGF but also by Ono 1301 itself. It also works through promoting synthesis of hepatocyte growth factor and increasing cyclic AMP concentration via IP-receptor signaling.

• Smiles:

  C(CO/N=C(\C1=CC=CC=C1)/C=2C=CC=NC2)C=3C=4C(=C(OCC(O)=O)C=CC4)CCC3

• Molecular Formula:

  C26H24N2O4

• Molecular Weight:

  428.48

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  176391-41-6