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DCB-3503

CAT: 0931-T27128-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T27128-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
87302-58-7
Target
Others, HSP, CDK
Related Pathways
Metabolism, Cytoskeletal Signaling, Cell Cycle/Checkpoint, Others
Bioactivity
Tylophorine analog DCB-3503 is a potential anticancer and immunosuppressive agent. DCB-3503 suppresses the translation of cellular regulatory proteins, including cyclin D1, at the elongation step. DCB-3503 allosterically regulates the ATPase and chaperone activities of HSC70 by promoting ATP hydrolysis in the presence of specific RNA binding motifs (AUUUA) of cyclin D1 mRNA.
Smiles
O[C@H]1C=2C(=C3C(=C4C2C=C(OC)C(OC)=C4)C=C(OC)C(OC)=C3)CN5[C@]1(CCC5)[H]
Molecular Formula
C24H27NO5
Molecular Weight
409.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Dcb-3503
CAS Number87302-58-7
PubChem CID402628
IUPAC Name(13aS,14S)-2,3,6,7-tetramethoxy-9,11,12,13,13a,14-hexahydrophenanthro[9,10-f]indolizin-14-ol
Molecular FormulaC24H27NO5
Molecular Weight409.5
XLogP3.6
Topological Polar Surface Area60.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count30
Formal Charge0
Complexity604
SMILES
COC1=C(C=C2C(=C1)C3=C([C@@H]([C@@H]4CCCN4C3)O)C5=CC(=C(C=C25)OC)OC)OC
InChI
InChI=1S/C24H27NO5/c1-27-19-8-13-14-9-20(28-2)22(30-4)11-16(14)23-17(15(13)10-21(19)29-3)12-25-7-5-6-18(25)24(23)26/h8-11,18,24,26H,5-7,12H2,1-4H3/t18-,24+/m0/s1
InChIKey
JWHWLMNMGLICQZ-MHECFPHRSA-N
Chemical Structure
2D Structure
2D structure of Dcb-3503
CAS: 87302-58-7
CID: 402628
Formula: C24H27NO5
MW: 409.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight409.5
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass409.18892296
Monoisotopic Mass409.18892296
Topological Polar Surface Area60.4 Ų
Heavy Atom Count30
Formal Charge0
Complexity604
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-111244DCB-3503
TRC-D195153-50MGDCB
GTR19204635-01Z-Asp-DCB
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