Bim-BLK-A

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  Bim-BLK-A efficiently blocks Bim-induced apoptosis after Bax is activated on the mitochondria. The cellular target of Bim-BLK-A was identified to be the succinate dehydrogenase subunit B (SDHB) protein of complex II of the mitochondrial electron transfer chain (ETC) . Bim-BLK-A protects the integrity of the ETC and allows treated cells to continue to proliferate after apoptosis induction.

• Smiles:

  O=C1C=CC(C2=NC(S(=O)(C)=O)=NC(C(F)(F)F)=C2)=CN1CC3=CC=C(OC)C(OC)=C3

• Molecular Formula:

  C20H18F3N3O5S

• Molecular Weight:

  469.44

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C