BBR 2160

• Target:

  Calcium Channel|||Others

• Related Pathways:

  Metabolism|||Membrane transporter/Ion channel|||Others

• Bioactivity:

  BBR 2160 is a dihydropyridine derivative belonging to the group of the so-called tiampidine. BBR 2160 has calcium-antagonistic properties in cardiac tissue. Intracellular microelectrodes have been used to characterize the electrophysiological properties of BBR 2160 on guinea-pig papillary muscle and sheep Purkinje fibres. BBR 2160 (10 (-7) and 10 (-6) M) dose dependently decreased the contractility of driven papillary muscle and Purkinje fibre. This effect was associated with a lowering of the plateau phase and a shortening of action potential duration in papillary muscle.

• Smiles:

  C(OCC)(=O)C=1C(C(C(OC)=O)=C(C)NC1CSCCNC=O)C2=CC(N(=O)=O)=CC=C2

• Molecular Formula:

  C21H25N3O7S

• Molecular Weight:

  463.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  118587-22-7