AZ-4217

• Target:

  Beta-Secretase|||Others

• Related Pathways:

  Neuroscience|||Others

• Bioactivity:

  AZ-4217 is a high potency BACE inhibitor. It displays acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. AZ-4217 has IC50 160 pM in human SH-SY5Y cells with an excellent in vivo efficacy.

• Smiles:

  NC1=N[C@](C=2C1=C(F)C=CC2)(C3=CN(CC)C(=O)C(C)=C3)C4=CC(=CC=C4)C=5C=C(C#CC)C=NC5

• Molecular Formula:

  C30H25FN4O

• Molecular Weight:

  476.54

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1383846-83-0