AVN-101

• Target:

  Histamine Receptor|||5-HT Receptor|||Adrenergic Receptor

• Related Pathways:

  Immunology/Inflammation|||GPCR/G Protein|||Neuroscience

• Purity:

  0.9973

• Bioactivity:

  AVN-101 is a highly potent 5-HT7 receptor antagonist with a Ki value of 153 pM. AVN-101 also exhibits considerable affinity for histamine H1 (Ki value of 0.58 nM) and adrenergic ?2A, ?2B and ?2C (Ki values ??of 0.41-3.6 nM) receptors. AVN-101 has shown good oral bioavailability and brain-blood barrier permeability, low toxicity and reasonable efficacy in animal models of central nervous system diseases.

• Smiles:

  Cl.CN1CCC2=C(C1)C1=CC(C)=CC=C1N2CCC1=CC=CC=C1

• Molecular Formula:

  C21H25ClN2

• Molecular Weight:

  340.89

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1061354-48-0