AM-1430

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  AM-1430 is a potent and selective PI3K? inhibitor. AM-1430 has cellular potency: pAKT IC50 = 0.8 nM; HWB, u (pAKT) IC 50 = 7.7 nM. Rat KLH: IgG ED50 -= 0.016 mg/kg; IhM ED50 = 0.015 mg/kg. Rat PK Clu = 1.7 L/hr/kg.

• Smiles:

  CNC (C1=C (C2=NC=CC=C2) C ([C@H] (C) NC3=NC=NC (N) =C3C#N) =NC4=CC=CC (F) =C14) =O

• Molecular Formula:

  C23H19FN8O

• Molecular Weight:

  442.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C