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AC-186

CAT: 0931-T26537-06Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T26537-06Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1421854-16-1
Target
Estrogen Receptor/ERR, Estrogen/progestogen Receptor
Related Pathways
Endocrinology/Hormones
Purity
0.9953
Bioactivity
AC-186 is a nonsteroidal estrogen receptor β (ERβ) agonist with different affinities for ERβ and ERα, with an EC50 of 6 nM for ERβ and 5000 nM for ERα. AC-186 has neuroprotective activity and has been used in the study of Parkinson's disease.
Smiles
FC=1C=CC=CC1C2(C3=CC=C(O)C=C3)CCC(F)(F)CC2
Molecular Formula
C18H17F3O
Molecular Weight
306.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

AC-186

structure in first source

CAS Number1421854-16-1
PubChem CID71245042
IUPAC Name4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Molecular FormulaC18H17F3O
Molecular Weight306.3
XLogP5.3
Topological Polar Surface Area20.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity367
SMILES
C1CC(CCC1(C2=CC=C(C=C2)O)C3=CC=CC=C3F)(F)F
InChI
InChI=1S/C18H17F3O/c19-16-4-2-1-3-15(16)17(9-11-18(20,21)12-10-17)13-5-7-14(22)8-6-13/h1-8,22H,9-12H2
InChIKey
HSMUKSLNDJOZQG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AC-186
CAS: 1421854-16-1
CID: 71245042
Formula: C18H17F3O
MW: 306.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight306.3
XLogP35.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass306.12314965
Monoisotopic Mass306.12314965
Topological Polar Surface Area20.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity367
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B2980-5AC-186
5053/10AC 186
227789STF 186-450*150-B7541 AC Signs
256403STF 186-297*105-B7527 AC Signs
227790STF 186-450*150-B7527 AC Signs
256402STF 186-297*105-B7541 AC Signs
564802TL12-186
HY-117981OUP-186
BML-FR103-0050MCI-186
ABC-TC0130CERV-186

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