Filanesib TFA

• Target:

  Kinesin|||Others

• Related Pathways:

  Others|||Cytoskeletal Signaling

• Bioactivity:

  Filanesib (ARRY-520) targets the kinesin spindle protein (KSP) with potential antineoplastic activity. ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing.

• Smiles:

  C(C(O)=O)(F)(F)F.C(CCN)[C@@]1(N(C(N(OC)C)=O)N=C(S1)C2=C(F)C=CC(F)=C2)C3=CC=CC=C3

• Molecular Formula:

  C22H23F5N4O4S

• Molecular Weight:

  534.5

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1781834-99-8