GNE-490

• Target:

  PI3K|||mTOR

• Related Pathways:

  PI3K/Akt/mTOR signaling

• Purity:

  0.9977

• Bioactivity:

  GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3K?, PI3K?, PI3K? and PI3K?, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50 = 750 nM) .

• Smiles:

  Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2sc(cc2n1)C(C)(C)O

• Molecular Formula:

  C18H22N6O2S

• Molecular Weight:

  386.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1033739-92-2