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Dasatinib hydrochloride

CAT: 0931-T22303-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T22303-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
854001-07-3
Target
Autophagy, Apoptosis, c-Kit, Src, Bcr-Abl
Related Pathways
Autophagy, Tyrosine Kinase/Adaptors, Apoptosis, Angiogenesis, Cytoskeletal Signaling
Purity
0.9998
Bioactivity
Dasatinib hydrochloride (BMS-354825 HCl) (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib hydrochloride hydrochloride also induces Apoptosis and Autophagy.
Smiles
Cl.Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Molecular Formula
C22H27Cl2N7O2S
Molecular Weight
524.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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