Dasatinib monohydrate

• Target:

  Apoptosis|||Ephrin Receptor|||Autophagy|||Src|||c-Kit|||Bcr-Abl

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Apoptosis|||Autophagy|||Angiogenesis|||Cytoskeletal Signaling

• Purity:

  >99.99%

• Bioactivity:

  Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activities of these kinases. Apparently, because of its less stringent binding affinity for the BCR-ABL kinase, Dasatinib monohydrate has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations.

• Smiles:

  N1cc(sc1Nc1nc(nc(N2CCN(CC2)CCO)c1)C)C(=O)Nc1c(cccc1C)Cl.O

• Molecular Formula:

  C22H28ClN7O3S

• Molecular Weight:

  506.03

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  863127-77-9