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Dasatinib monohydrate

CAT: 0931-T1448L-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T1448L-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
863127-77-9
Target
Apoptosis, Ephrin Receptor, Autophagy, Src, c-Kit, Bcr-Abl
Related Pathways
Tyrosine Kinase/Adaptors, Apoptosis, Autophagy, Angiogenesis, Cytoskeletal Signaling
Purity
>99.99%
Bioactivity
Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activities of these kinases. Apparently, because of its less stringent binding affinity for the BCR-ABL kinase, Dasatinib monohydrate has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations.
Smiles
n1cc(sc1Nc1nc(nc(N2CCN(CC2)CCO)c1)C)C(=O)Nc1c(cccc1C)Cl.O
Molecular Formula
C22H28ClN7O3S
Molecular Weight
506.03
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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