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PF-4708671

CAT: 0931-T2002-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T2002-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1255517-76-0
Target
Autophagy, S6 Kinase
Related Pathways
MAPK, Autophagy, PI3K/Akt/mTOR signaling
Purity
0.9998
Bioactivity
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671 (PF4708671) is potent for S6K1 (Ki50=20 nM, IC50=160 nM) .
Smiles
CCc1cncnc1N1CCN(Cc2nc3cc(ccc3[nH]2)C(F)(F)F)CC1
Molecular Formula
C19H21F3N6
Molecular Weight
390.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

PF-4708671

PF-4708671 is an organic molecular entity. It has a role as an inhibitor.

CAS Number1255517-76-0
PubChem CID51371303
IUPAC Name2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole
Molecular FormulaC19H21F3N6
Molecular Weight390.4
XLogP3.2
Topological Polar Surface Area60.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity510
SMILES
CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F
InChI
InChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)
InChIKey
FBLPQCAQRNSVHB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PF-4708671
CAS: 1255517-76-0
CID: 51371303
Formula: C19H21F3N6
MW: 390.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight390.4
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass390.17797918
Monoisotopic Mass390.17797918
Topological Polar Surface Area60.9 Ų
Heavy Atom Count28
Formal Charge0
Complexity510
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
406432PF-4708671
sc-361288APF 4708671

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