SD-36

• Target:

  PROTACs|||Apoptosis|||STAT

• Related Pathways:

  JAK/STAT signaling|||Stem Cells|||PROTAC|||Apoptosis

• Purity:

  >99.99%

• Bioactivity:

  SD-36 is a selective and efficient STAT3 protein degrader (Kd=~50 nM) with antitumor activity that promotes growth inhibition and induces apoptosis by inhibiting Mcl-1 in gliomas.SD-36 inhibits the transcriptional activity of STAT3.

• Smiles:

  C(N[C@H](C(NC(C1=CC=CC=C1)C2=CC=CC=C2)=O)CCC(N)=O)(=O)[C@H]3N4[C@](CC3)(CCN(C(CCCCCC#CC5=C6C(C(=O)N(C6)C7C(=O)NC(=O)CC7)=CC=C5)=O)C[C@H](NC(=O)C8=CC=9C(N8)=CC=C(C(P(=O)(O)O)(F)F)C9)C4=O)[H]

• Molecular Formula:

  C59H62F2N9O12P

• Molecular Weight:

  1158.15

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2429877-44-9