Palbociclib-propargyl

• Target:

  Others|||Ligands for Target Protein for PROTAC

• Related Pathways:

  Others|||PROTAC

• Bioactivity:

  Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent DC50 value of 2.1 nM against CDK6[1].

• Smiles:

  CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCN(CC#C)CC3)nc2n(C2CCCC2)c1=O

• Molecular Formula:

  C27H31N7O2

• Molecular Weight:

  485.58

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2366269-23-8