PTC-028

CAT: 0931-T16680-05Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T16680-05Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1782970-28-8

Target

Apoptosis, BMI-1

Related Pathways

DNA Damage/DNA Repair, Apoptosis, Cell Cycle/Checkpoint

Purity

0.9825

Bioactivity

PTC-028 selectively suppresses cancer cells whereas normal cells remain unaffected. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. The depletion of BMI-1 by PTC-028 causes caspase-mediated apoptosis.

Smiles

Cc1nc2cc(F)c(F)cc2n1-c1cncc(Nc2ccc(cc2)C(F)(F)F)n1

Molecular Formula

C19H12F5N5

Molecular Weight

405.32

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

6-(5,6-Difluoro-2-methyl-1H-benzimidazol-1-yl)-N-(4-(trifluoromethyl)phenyl)-2-pyrazinamine

CAS Number	1782970-28-8
PubChem CID	73427235
IUPAC Name	6-(5,6-difluoro-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine
Molecular Formula	C19H12F5N5
Molecular Weight	405.3
XLogP	4.7
Topological Polar Surface Area	55.6
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Heavy Atom Count	29
Formal Charge	0
Complexity	556

SMILES

CC1=NC2=CC(=C(C=C2N1C3=NC(=CN=C3)NC4=CC=C(C=C4)C(F)(F)F)F)F

InChI

InChI=1S/C19H12F5N5/c1-10-26-15-6-13(20)14(21)7-16(15)29(10)18-9-25-8-17(28-18)27-12-4-2-11(3-5-12)19(22,23)24/h2-9H,1H3,(H,27,28)

InChIKey

JEZGPBWIZWPDHP-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1782970-28-8

CID: 73427235

Formula: C19H12F5N5

MW: 405.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	405.3
XLogP3	4.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Exact Mass	405.10128621
Monoisotopic Mass	405.10128621
Topological Polar Surface Area	55.6 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	556
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
T9901A-1791-01	MORAb-028
T12936-01	SMP-028
T38562-01	AKN-028
T210808-01	PTC-700
T61358	AKN-028 acetate
T29802-01	AKN-028 trifluoroacetate
T2345-01	PTC-209
T6178-01	PTC-209 hydrobromide
T40279-01	GLP-1R modulator L7-028
T28470-01	PTC-510 TFA salt

Alternative Products

Catalog	Name
BA2872-25	PTC-028
BP168106-01	PTC 028
A16812-100	PTC-028 100mg
A16812-5	PTC-028 5mg

PTC-028

Chemical Information

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