PR-924

• Target:

  Proteasome|||Apoptosis

• Related Pathways:

  Ubiquitination|||Proteases/Proteasome|||Apoptosis

• Bioactivity:

  PR-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit LMP-7 (IC50: 22 nM) . PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities. PR-924 covalently modifies proteasomal N-terminal threonine active sites.

• Smiles:

  C[C@@H] (NC (=O) C1=C (C) c2ccccc2C1) C (=O) N[C@@H] (Cc1c[nH]c2ccccc12) C (=O) N[C@@H] (Cc1ccccc1) C (=O) [C@@]1 (C) CO1

• Molecular Formula:

  C37H38N4O5

• Molecular Weight:

  618.72

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1416709-79-9