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PR-924

CAT: 0931-T16568-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-T16568-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1416709-79-9
Target
Proteasome|||Apoptosis
Related Pathways
Ubiquitination|||Proteases/Proteasome|||Apoptosis
Bioactivity
PR-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit LMP-7 (IC50: 22 nM) . PR-924 inhibits growth and triggers apoptosis in multiple myeloma (MM) cells. PR-924 has antitumor activities. PR-924 covalently modifies proteasomal N-terminal threonine active sites.
Smiles
C[C@@H](NC(=O)C1=C(C)c2ccccc2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1
Molecular Formula
C37H38N4O5
Molecular Weight
618.72
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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