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KL1333

CAT: 0931-T16342-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T16342-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1800405-30-4
Target
Reductase, NADPH, Mitochondrial Metabolism
Related Pathways
Metabolism, Endocrinology/Hormones
Purity
0.9989
Bioactivity
KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD (P) H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.
Smiles
CC(C)c1nc-2c([nH]1)C(=O)C(=O)c1ccccc-21
Molecular Formula
C14H12N2O2
Molecular Weight
240.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Kl-1333
CAS Number1800405-30-4
PubChem CID91820639
IUPAC Name2-propan-2-yl-3H-benzo[e]benzimidazole-4,5-dione
Molecular FormulaC14H12N2O2
Molecular Weight240.26
XLogP2.3
Topological Polar Surface Area62.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count18
Formal Charge0
Complexity380
SMILES
CC(C)C1=NC2=C(N1)C(=O)C(=O)C3=CC=CC=C32
InChI
InChI=1S/C14H12N2O2/c1-7(2)14-15-10-8-5-3-4-6-9(8)12(17)13(18)11(10)16-14/h3-7H,1-2H3,(H,15,16)
InChIKey
AJFWITSBVLLDCC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Kl-1333
CAS: 1800405-30-4
CID: 91820639
Formula: C14H12N2O2
MW: 240.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight240.26
XLogP32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass240.089877630
Monoisotopic Mass240.089877630
Topological Polar Surface Area62.8 Ų
Heavy Atom Count18
Formal Charge0
Complexity380
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-128895-01KL1333
GTR19263902-01KL1333 hydrochloride
A17234-100KL1333 100mg
A17234-5KL1333 5mg
HY-128895AKL1333 (hydrochloride)
A17234-50KL1333 50mg
A17234-25KL1333 25mg
A17234-10KL1333 10mg
A17234-1KL1333 1mg
A17234-10mM-DKL1333 10mM * 1mL in DMSO

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