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KL1333

CAT: 0804-HY-128895-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128895-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD (P) H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures[1][2].
CAS Number
1800405-30-4
UNSPSC
12352005
Target
Mitochondrial Metabolism; Quinone Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nqo1-activator-1.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C2N=C(C(C)C)N1)C(C3=C2C=CC=C3)=O
Molecular Formula
C14H12N2O2
Molecular Weight
240.26
References & Citations
[1]Seo KS, et al. KL1333, a Novel NAD+ Modulator, Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts. Front Neurol. 2018;9:552. Published 2018 Jul 5.|[2]Lee HS, et al. KL1333, a derivative of β-lapachone, protects against cisplatin-induced ototoxicity in mouse cochlear cultures. Biomed Pharmacother. 2020;126:110068.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

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GTR19155682-01KL1333
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A17234-100KL1333 100mg
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