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KL1333 hydrochloride

CAT: 0013-GTR19263902-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263902-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KL1333 hydrochloride is an orally effective NAD+ modulator that acts as a substrate for NAD (P) H: quinone oxidoreductase 1 (NQO1), leading to increased intracellular NAD+ levels through NADH oxidation. Elevated NAD+ subsequently activates SIRT1 and AMPK, which in turn activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in fibroblasts of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) . It also has a protective effect against cisplatin-induced ototoxicity in cultured mouse cochlea.
CAS Number
1800406-26-1
Field of Research
Metabolism Research
Smiles
Cl.O=C1C (=O) C=2C=CC=CC2C=3NC (=NC13) C (C) C
Molecular Formula
C14H13ClN2O2
Molecular Weight
276.72
Storage Conditions
-20°C
Notes
For research use only.

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