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KL1333

CAT: 0931-T16342-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T16342-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1800405-30-4
Target
Reductase, NADPH, Mitochondrial Metabolism
Related Pathways
Metabolism, Endocrinology/Hormones
Purity
0.9989
Bioactivity
KL1333 (NQO1 activator 1) enhances energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. Elevated NAD+ levels trigger the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. NQO1 activator 1 is an orally available NAD+ modulator. It reacts with NAD (P) H: NQO1 as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation.
Smiles
CC(C)c1nc-2c([nH]1)C(=O)C(=O)c1ccccc-21
Molecular Formula
C14H12N2O2
Molecular Weight
240.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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