M-110

• Target :

  Pim

• Related Pathways :

  Chromatin/Epigenetic|||JAK/STAT signaling

• Purity :

  0.9955

• Bioactivity :

  M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases, showing a preference for PIM-3 (IC50=47 nM), and inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 ?M. M-110 also inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 ?M.

• Smiles :

  CC\C(=N/NC(=O)c1ccnc(NCCCN2CCOCC2)c1)c1ccc(Cl)cc1O

• Molecular Formula :

  C22H28ClN5O3

• Molecular Weight :

  445.94

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1395048-49-3