M-110

• Target:

  Pim

• Related Pathways:

  Chromatin/Epigenetic|||JAK/STAT signaling

• Purity:

  0.9955

• Bioactivity:

  M-110 is a highly selective, ATP-competitive inhibitor of PIM kinases, showing a preference for PIM-3 (IC50=47 nM), and inhibits PIM-1 and PIM-2 with similar IC50s of 2.5 ?M. M-110 also inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 ?M.

• Smiles:

  CC\C(=N/NC(=O)c1ccnc(NCCCN2CCOCC2)c1)c1ccc(Cl)cc1O

• Molecular Formula:

  C22H28ClN5O3

• Molecular Weight:

  445.94

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1395048-49-3