FTI-2153

CAT: 0931-T15353-02Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0931-T15353-02Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

344900-92-1

Target

Others, Transferase

Related Pathways

Others, Metabolism

Bioactivity

FTI-2153 is a potent and highly selective farnesyltransferase (FTase) inhibitor (IC50: 1.4 nM) that is over 3000-fold more effective at blocking H-Ras (IC50: 10 nM) than Rap1A processing.

Smiles

COC(=O)[C@H](CCSC)NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1ccccc1C

Molecular Formula

C25H30N4O3S

Molecular Weight

466.6

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

methyl (2S)-2-[[4-[(1H-imidazol-5-ylmethylamino)methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoate

CAS Number	344900-92-1
PubChem CID	6918458
IUPAC Name	methyl (2S)-2-[[4-[(1H-imidazol-5-ylmethylamino)methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoate
Molecular Formula	C25H30N4O3S
Molecular Weight	466.6
XLogP	3.2
Topological Polar Surface Area	121
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	12
Heavy Atom Count	33
Formal Charge	0
Complexity	622

SMILES

CC1=CC=CC=C1C2=C(C=CC(=C2)CNCC3=CN=CN3)C(=O)N[C@@H](CCSC)C(=O)OC

InChI

InChI=1S/C25H30N4O3S/c1-17-6-4-5-7-20(17)22-12-18(13-26-14-19-15-27-16-28-19)8-9-21(22)24(30)29-23(10-11-33-3)25(31)32-2/h4-9,12,15-16,23,26H,10-11,13-14H2,1-3H3,(H,27,28)(H,29,30)/t23-/m0/s1

InChIKey

KZCMMZOLCBZLNG-QHCPKHFHSA-N

Chemical Structure

2D Structure

CAS: 344900-92-1

CID: 6918458

Formula: C25H30N4O3S

MW: 466.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	466.6
XLogP3	3.2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	12
Exact Mass	466.20386201
Monoisotopic Mass	466.20386201
Topological Polar Surface Area	121 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	622
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
T71375-01	FTI-2600
T70372-01	FTI-249
T68923-01	FTI-2628
T62675-01	FTI-277
T11331L-01	FTI 276
T11330L-01	FTI-2148
T70818-01	TC-2153
T11331-01	FTI 276 TFA
T2700-01	FTI-277 hydrochloride
T11330-01	FTI-2148 diTFA

Alternative Products

Catalog	Name
GTR19203329-01	FTI-2153
GTR19185068-01	FTI-2153 TFA
HY-123242A-01	FTI-2153 (TFA)
MBS131611	AT-2153
BA5050-10	TC-2153
HY-118916-01	FTI-2148
HY-15872	FTI-277
MBS5802822	FTI 277
MBS5811478	FTI-2628
GTR19209306-01	FTI-2600

FTI-2153

Chemical Information

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