Products for Research Use Only
RegisterLogin

(±) -10-Hydroxycamptothecin

CAT: 0931-T1521-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T1521-01Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
64439-81-2
Target
Topoisomerase
Related Pathways
DNA Damage/DNA Repair
Purity
0.9958
Bioactivity
(±) -10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Smiles
CCC1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)cc4cc3Cn1c2=O
Molecular Formula
C20H16N2O5
Molecular Weight
364.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

4-Ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione

See also: Hydroxycamptothecin (annotation moved to) ... View More ...

CAS Number64439-81-2
PubChem CID4330531
IUPAC Name19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
Molecular FormulaC20H16N2O5
Molecular Weight364.4
XLogP0.6
Topological Polar Surface Area100
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Heavy Atom Count27
Formal Charge0
Complexity774
SMILES
CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O
InChI
InChI=1S/C20H16N2O5/c1-2-20(26)14-7-16-17-11(5-10-6-12(23)3-4-15(10)21-17)8-22(16)18(24)13(14)9-27-19(20)25/h3-7,23,26H,2,8-9H2,1H3
InChIKey
HAWSQZCWOQZXHI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-Ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
CAS: 64439-81-2
CID: 4330531
Formula: C20H16N2O5
MW: 364.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight364.4
XLogP30.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count1
Exact Mass364.10592162
Monoisotopic Mass364.10592162
Topological Polar Surface Area100 Ų
Heavy Atom Count27
Formal Charge0
Complexity774
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T4952-019-Hydroxycamptothecin
TN2460-0112-Ethyl-9-hydroxycamptothecin
T201468-01P6P-10,10
T24963-0110-Methyl-10-deazaaminopterin
T200957-01Aβ-IN-10
T33653-01Neurokinin A (4-10), nle (10) -
TYD-02011-0110- (tert-Butoxy) -10-oxodecanoic acid
TMIH-0024-0110,11-Dihydro-10-hydroxycarbamazepine-d4
TN257310-O-Coumaroyl-10-O-deacetylasperuloside
T83553-01(4S) -10-Nor-calamenen-10-one

Alternative Products

CatalogName
GTR19175337-01(±) -10-Hydroxycamptothecin
N2591-2010-Hydroxycamptothecin
HY-N0095-01(S) -10-Hydroxycamptothecin
TB0033-100010-Hydroxycamptothecin(e)
B4745-100(S)-10-Hydroxycamptothecin

Popular Products