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DBPR728

CAT: 0931-T88056-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T88056-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2702965-64-6
Target
Aurora Kinase
Related Pathways
Chromatin/Epigenetic, Cell Cycle/Checkpoint
Bioactivity
DBPR728, an acyl prodrug of 6K465, possesses fewer hydrogen bond donors and functions as an Aurora kinase inhibitor that targets MYC family cancer proteins, showing antitumor potential. It can effectively inhibit cancers overexpressing C-MYC and N-MYC, offering a 10-fold improvement in oral bioavailability over 6K465.
Smiles
O=C(C=1C=CC=C(Cl)C1F)N2CCC(NC=3N=C(C=C(N3)N4CCN(CC)CC4)NC5=CC(=NN5C(=O)CC)C)CC2
Molecular Formula
C29H37ClFN9O2
Molecular Weight
598.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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