ERD-308

• Target:

  PROTACs|||Estrogen Receptor/ERR

• Related Pathways:

  PROTAC|||Endocrinology/Hormones

• Bioactivity:

  ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively) .ERD-308 is a highly potent PROTAC degrader of estrogen receptor (ER) for ER positive breast cancer treatment.

• Smiles:

  C(=O)(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(O)C=C3)C4=CC=C(OCCN(CCCCCOCC(N[C@H](C(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C=7SC=NC7C)=O)C[C@@H](O)C5)[C@](C)(C)C)=O)CC)C=C4

• Molecular Formula:

  C55H65N5O9S2

• Molecular Weight:

  1004.26

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2320561-35-9