KAG-308

• Target:

  Prostaglandin Receptor

• Related Pathways:

  GPCR/G Protein|||Immunology/Inflammation

• Bioactivity:

  KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing, which potently inhibits TNF-? production.

• Smiles:

  [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)[C@H](C)c3cccc(C)c3)[C@@]1([H])C(F)(F)\C(O2)=C\CCCc1nnn[nH]1

• Molecular Formula:

  C24H30F2N4O3

• Molecular Weight:

  460.52

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1215192-68-9