KAG-308

CAT: 0931-T15642-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T15642-01Size:25 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1215192-68-9
Target
Prostaglandin Receptor
Related Pathways
GPCR/G Protein|||Immunology/Inflammation
Bioactivity
KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing, which potently inhibits TNF-? production.
Smiles
[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)[C@H](C)c3cccc(C)c3)[C@@]1([H])C(F)(F)\C(O2)=C\CCCc1nnn[nH]1
Molecular Formula
C24H30F2N4O3
Molecular Weight
460.52
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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