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UK-101

CAT: 0931-T13247-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T13247-03Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1000313-40-5
Target
Apoptosis, Proteasome
Related Pathways
Apoptosis, Proteases/Proteasome, Ubiquitination
Purity
>99.99%
Bioactivity
UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting β1i (LMP2), β1c (LMP2), and β5 (LMP2), with IC50s of 104 nM, 15 μM, and 1 μM, respectively. UK-101 exhibits a 144-fold and 10-fold higher affinity for β1i than for the distribution of β1c and β5 subunits. UK-101 induces apoptosis and can be used to study prostate cancer-related diseases.
Smiles
C([C@@H](NC([C@@H](NC(CCCCCC)=O)C)=O)CC(C)C)(=O)[C@@]1(CO[Si](C(C)(C)C)(C)C)CO1
Molecular Formula
C25H48N2O5Si
Molecular Weight
484.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

CID 24752894
CAS Number1000313-40-5
PubChem CID24752894
IUPAC NameN-[(2S)-1-[[(2S)-1-[(2S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]oxiran-2-yl]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]heptanamide
Molecular FormulaC25H48N2O5Si
Molecular Weight484.7
Topological Polar Surface Area97
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count16
Heavy Atom Count33
Formal Charge0
Complexity674
SMILES
CCCCCCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)[C@]1(CO1)CO[Si](C)(C)C(C)(C)C
InChI
InChI=1S/C25H48N2O5Si/c1-10-11-12-13-14-21(28)26-19(4)23(30)27-20(15-18(2)3)22(29)25(16-31-25)17-32-33(8,9)24(5,6)7/h18-20H,10-17H2,1-9H3,(H,26,28)(H,27,30)/t19-,20-,25-/m0/s1
InChIKey
OHYPIFPQEYUPDQ-RLSLOFABSA-N
Chemical Structure
2D Structure
2D structure of CID 24752894
CAS: 1000313-40-5
CID: 24752894
Formula: C25H48N2O5Si
MW: 484.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight484.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count16
Exact Mass484.33324917
Monoisotopic Mass484.33324917
Topological Polar Surface Area97 Ų
Heavy Atom Count33
Formal Charge0
Complexity674
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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