MS4322

CAT: 0804-HY-141877-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-141877-01Size:1 mg
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Description
MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092) ; Blue: E3 ligase ligand HY-112078) ; Black: linker (HY-124780) ; E3+linker (HY-173093) ) [1].
CAS Number
[2375432-47-4]
Product Name Alternative
YS43-22
UNSPSC
12352005
Target
Histone Methyltransferase; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms4322.html
Purity
99.22
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=NC(NC2CN(C(COCCOCCOCCOCCOCC(N[C@H](C(N3[C@H](C(N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C)=O)C[C@@H](O)C3)=O)C(C)(C)C)=O)=O)C2)=C1)NC[C@H](O)CN6CC7=C(C=CC=C7)CC6
Molecular Formula
C55H76N10O12S
Molecular Weight
1101.32
References & Citations
[1]Shen Y, et al. Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders. J Med Chem. 2020 Sep 10;63 (17) :9977-9989.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; DOT1L; EHMT1/GLP/KMT1D; EHMT2/G9a/KMT1C; EZH1; EZH2; MDM2; NSD2/MMSET/WHSC1; PRMT1; PRMT3; PRMT4; PRMT5; PRMT6; PRMT7; PRMT8; SETD2/KMT3A; SETD7/KMT7; SETD8/KMT5A; SETDB1/KMT2G; SMYD2; SMYD3; SUV39H2/KMT1B; von Hippel-Lindau (VHL)

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