MS4322

• Description :

  MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092) ; Blue: E3 ligase ligand HY-112078) ; Black: linker (HY-124780) ; E3+linker (HY-173093) ) [1].

• Product Name Alternative :

  YS43-22

• UNSPSC :

  12352005

• Target :

  Histone Methyltransferase; PROTACs

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ms4322.html

• Purity :

  99.22

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=NC=NC(NC2CN(C(COCCOCCOCCOCCOCC(N[C@H](C(N3[C@H](C(N[C@H](C4=CC=C(C5=C(C)N=CS5)C=C4)C)=O)C[C@@H](O)C3)=O)C(C)(C)C)=O)=O)C2)=C1)NC[C@H](O)CN6CC7=C(C=CC=C7)CC6

• Molecular Formula :

  C55H76N10O12S

• Molecular Weight :

  1101.32

• References & Citations :

  [1]Shen Y, et al. Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders. J Med Chem. 2020 Sep 10;63 (17) :9977-9989.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon; DOT1L; EHMT1/GLP/KMT1D; EHMT2/G9a/KMT1C; EZH1; EZH2; MDM2; NSD2/MMSET/WHSC1; PRMT1; PRMT3; PRMT4; PRMT5; PRMT6; PRMT7; PRMT8; SETD2/KMT3A; SETD7/KMT7; SETD8/KMT5A; SETDB1/KMT2G; SMYD2; SMYD3; SUV39H2/KMT1B; von Hippel-Lindau (VHL)

• CAS Number :

  [2375432-47-4]