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JNJ-63576253

CAT: 0804-HY-115282A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115282A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNJ-63576253 (TRC-253) is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells. JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC) [1].
CAS Number
2110428-64-1
Product Name Alternative
TRC-253
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jnj-63576253-hydrochloride.html
Purity
99.22
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
[H]Cl.O=C(N(C(N1C2=CC=C(N=C2)OC3CCNCC3)=S)C(C=C4C(F)(F)F)=CN=C4C#N)C51CCC5
Molecular Formula
C23H22ClF3N6O2S
Molecular Weight
538.97
References & Citations
[1]Zhang Z, et, al. Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC) . J Med Chem. 2021 Jan 28;64 (2) :909-924.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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