Products for Research Use Only
RegisterLogin

JNJ-63576253 5mg

CAT: 0628-A22530-5Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0628-A22530-5Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
2110426-27-0

Chemical Information

Jnj-63576253

Androgen Receptor Antagonist TRC253 is an orally bioavailable androgen receptor (AR) antagonist, with potential antineoplastic activity. Upon oral administration, AR antagonist TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes, inhibits the expression of genes that regulate prostate cancer cell proliferation, and may lead to an inhibition of growth of tumor cells in which AR is overexpressed and/or mutated. AR is often overexpressed and/or mutated in prostate cancers and plays a key role in proliferation, survival and chemoresistance of tumor cells.

CAS Number2110426-27-0
PubChem CID130229812
IUPAC Name5-[8-oxo-5-(6-piperidin-4-yloxy-3-pyridinyl)-6-sulfanylidene-5,7-diazaspiro[3.4]octan-7-yl]-3-(trifluoromethyl)pyridine-2-carbonitrile
Molecular FormulaC23H21F3N6O2S
Molecular Weight502.5
XLogP3
Topological Polar Surface Area126
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Heavy Atom Count35
Formal Charge0
Complexity884
SMILES
C1CC2(C1)C(=O)N(C(=S)N2C3=CN=C(C=C3)OC4CCNCC4)C5=CC(=C(N=C5)C#N)C(F)(F)F
InChI
InChI=1S/C23H21F3N6O2S/c24-23(25,26)17-10-15(13-29-18(17)11-27)31-20(33)22(6-1-7-22)32(21(31)35)14-2-3-19(30-12-14)34-16-4-8-28-9-5-16/h2-3,10,12-13,16,28H,1,4-9H2
InChIKey
OUEHJEYKNYQVRC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Jnj-63576253
CAS: 2110426-27-0
CID: 130229812
Formula: C23H21F3N6O2S
MW: 502.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight502.5
XLogP33
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count4
Exact Mass502.13987959
Monoisotopic Mass502.13987959
Topological Polar Surface Area126 Ų
Heavy Atom Count35
Formal Charge0
Complexity884
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
A22530-100JNJ-63576253 100mg
A22530-10JNJ-63576253 10mg
A22530-25JNJ-63576253 25mg
A22530-2JNJ-63576253 2mg
A22530-200JNJ-63576253 200mg
A22530-50JNJ-63576253 50mg
A22530-10mM-DJNJ-63576253 10mM * 1mL in DMSO
A18675-5JNJ-54175446 5mg
A19913-5JNJ-678 5mg
A20659-5JNJ-18038683 5mg

Alternative Products

CatalogName
KJD42864-01JNJ-63576253
207173JNJ-63576253 HCl
S9900-01JNJ-63576253 (TRC-253)
T8933-01JNJ-63576253 free base
HY-115282JNJ-63576253 (free base)
MBS131356JNJ-63533054 (JNJ63533054; JNJ 63533054)
MBS3603460-01JNJ-55308942
FPD27376-01JNJ-67856633
WRB44790-01JNJ 39758979
EAC98038-01JNJ-46281222

Popular Products